Fetal limb in bladder: A rare complication of vesicouterine fistula

Vesicouterine fistula (VUF) is a rare urogenital fistula that is even rarer during pregnancy. Even if pregnancy occurs, the outcomes appear to be very poor. The most of the cases are related to iatrogenic bladder injury during cesarean section. There is very limited literature on the pregnancy with VUF associated with herniation of fetus or fetal part(s) into the bladder cavity. Here, we report a case of pregnancy in a known case of untreated VUF. She presented at 23 weeks of gestation with features of premature rupture of membrane and herniation of fetal left lower limb inside the bladder cavity. Her pregnancy ended up with hysterotomy and the removal of a non-viable fetus along with the repair of the fistula. Hence, regardless of the severity of the signs and symptoms associated with VUF, clinicians should convince the patients for the repair of the fistula especially if the future pregnancy is contemplated

Diagnosis, early treatment and prevention of urinary complications after radical hysterectomy for cervical cancer / 中国医师杂志

Urinary system complication is one of the common and serious complications in radical operation of cervical cancer. Timely detection and treatment is the key to improve the outcome. This article mainly introduces the latest progress in the early diagnosis, treatment and prevention of ureter injury, bladder injury and postoperative urinary retention during radical operation of cervical cancer, in order to improve our ability to detect and treat urinary system complications in time, reduce the occurrence of serious complications and minimize the harm to patients.

Effect of polysaccharides from seeds of Vaccaria segetalis in alleviating urinary tract infection induced bladder injury by inhibiting NLRP3 inflammasome / 中国中药杂志

To study the mechanism of polysaccharides from seeds of Vaccaria segetalis( PSV) in the treatment of bacterial cystitis through the NLRP3 inflammasome pathway. The rat model of urinary tract infection was used and treated with PSV,and the urine and bladders were collected. The level of interleukin-10( IL-10) in rat urine was detected by enzyme linked immunosorbent assay( ELISA). Western blot and immunofluorescence staining were used to detect the expressions of sonic hedgehog( SHH) and NLRP3 inflammasome [NOD-like receptor thermoprotein domain 3( NLRP3),apoptosis associated speck like protein( ASC) and pro-caspase-1]. The expression of Toll-like receptor pathway was detected by RT-PCR. The death of 5637 cells induced by uropathogenic Escherichia coli( UPEC) and lactate dehydrogenase( LDH) release were evaluated using live/dead staining. The results showed that in the rat bladder,the expressions of SHH,NLRP3 inflammasomes and Toll-like receptors were significantly up-regulated,and NLRP3 inflammasomes were significantly activated by UPEC infection. The administration with PSV could significantly increase the concentration of IL-10 in urine,inhibit the expressions of SHH,NLRP3 inflammasomes and Toll-like receptors in bladder,and inhibit the activation of NLRP3 inflammasomes. A large number of 5637 cells were dead after UPEC infection and caused LDH production. PSV could significantly inhibit the death of 5637 cells and the release of LDH. In conclusion,PSV could inhibit the expression and activation of NLRP3 inflammasomes by inhibiting the Toll-like receptor pathway,thereby mitigating the bladder injury.

Is computed tomography cystography indicated in children with pelvic fractures? / 中华创伤杂志(英文版)

PURPOSE@#Pelvic fracture evaluation with abdominopelvic computed tomography (CT) and formal CT cystography for rule out of urine bladder injury have been commonly employed in pediatric trauma patients. The additional delayed imaging required to obtain optimal CT cystography is, however, associated with increased doses of ionizing radiation to pelvic organs and represent a significant risk in the pediatric population for future carcinogenic risk. We hypothesized that avoidance of routine CT cystography among pediatric pelvic fracture victims would not result in an appreciable rate of missed bladder injuries and would aid in mitigating the radiation exposure risk associated with these additional images.@*METHODS@#A retrospective cohort study involving blunt trauma pelvic fractures among pediatric trauma patients (age<14) between the years 1997 and 2016 was conducted utilizing the Israeli National Trauma Registry. Statistical analysis was performed using SAS statistical software version 9.4 via the tests of Chi-square test and two-sided Fisher's exact test. A p value of less than 0.05 was considered statistically significant.@*RESULTS@#A total of 1072 children were identified from the registry for inclusion. Mean age of patients was 7.7 years (range 0-14) and 713 (66.5%) were male. Overall mortality in this population was 4.1% (44/1072). Only 2.1% (23) of pediatric patients with pelvic fractures had bladder injury identified, with just 9 children having intraperitoneal bladder rupture (0.8% of all the patients).@*CONCLUSION@#The vast majority of blunt pediatric trauma victims with pelvic fractures do not have urine bladder injuries. Based on our study results we do not recommend the routine utilization of CT cystography in this unique population.

Dehiscencia de cistorrafia en pacientes con embolización de arterias uterinas por acretismo placentario: reporte de dos casos / Cistorraphy dehiscence in patients with uterine arteries embolization due to placentary acretism: report of two cases

Resumen: ANTECEDENTES: La incidencia de percretismo varía de 5-7% y de ésta, 78% corresponde a complicaciones relacionadas con la cirugía. Hasta la fecha existen pocos casos reportados de dehiscencia de cistorrafia posterior a la embolización de arterias uterinas. CASOS CLÍNICOS: Caso 1. Paciente de 34 años, con embarazo de 36 semanas y diagnóstico de acretismo placentario. El tratamiento consistió en embolización de arterias uterinas e histerectomía subtotal, con lesión vesical reparada sin complicaciones. Dos semanas después del alta hospitalaria acudió a consulta por pérdida de orina y fiebre (pielonefritis aguda); se estableció el diagnóstico de dehiscencia de cistorrafia por tomografía y cistografía retrógrada. Se realizó cateterización ureteral bilateral, laparotomía exploradora con traquelectomía, resección de los bordes necróticos vesicales y cistorrafia. Caso 2. Paciente de 30 años, con embarazo de 37 semanas y acretismo placentario; se aplicó tratamiento similar al caso 1, del que devino una lesión vesical reparada sin complicaciones. Durante la hospitalización permaneció en vigilancia por hemorragia obstétrica e infección urinaria con mala evolución; dos semanas después tuvo pérdida de orina, por lo que se efectuaron: cistoscopia, tomografía y cistografía retrógrada. Se estableció el diagnóstico de dehiscencia de cistorrafia. Durante la cirugía se localizó el defecto por cistoscopia e histeroscopia, se cateterizaron los uréteres de ambos lados; posteriormente, mediante acceso laparoscópico, se resecaron los bordes vesicales necróticos y se complementó con cistorrafia. Ambas pacientes evolucionaron sin complicaciones. CONCLUSIÓN: La dehiscencia de cistorrafia en pacientes con embolización de arterias uterinas es una complicación excepcional. La sospecha diagnóstica y el tratamiento oportunos, con resección de los bordes necróticos y cistorrafia, se asocian con mayor tasa de éxito.

Abstract: BACKGROUND: The incidence of percretism is 5-7% with 78% of complications associated with surgical management. There are few reported cases of cystorraphy dehiscence after uterine arteries embolization. CLINICAL CASES: Case 1. A 34 years old patient with a pregnancy of 36 5/7 weeks and acretism; she was treated with uterine artery embolization plus subtotal hysterectomy with bladder injury repaired without complications. She was discharged, and in 2 weeks she consulted for vaginal urine loss and fever (acute pyelonephritis); cystorraphy dehiscence was diagnosed with support of tomography and retrograde cystography. Bilateral ureteral catheterization, laparotomy with trachelectomy plus resection of bladder necrotic edges and cystorraphy were performed. Case 2. A 30 years old patient with a pregnancy of 37 5/7 weeks and acretism; equal treatment of acretism was given with bladder injury repaired without complications. She was hospitalized in surveillance for obstetric haemorrhage and urinary infection with torpid evolution; she referred vaginal urine loss at 2 weeks, so cystoscopy, tomography and retrograde cystography were performed which diagnosed cystorraphy dehiscence. In surgery the bladder defect was located by cystoscopy and hysteroscopy and bilateral ureters were catheterized; subsequently, by laparoscopic approach necrotic bladder edges were resected and cystorraphy was performed. Both patients without complications and with successful postoperative evolution. CONCLUSION: Cystorraphy dehiscence in embolized patients is extremely rare; however, it should be considered as a possible complication. Diagnostic suspicion and timely management with resection of necrosis and new cystorraphy, achieve greater success.

Clinical analysis of iatrogenic ureteral injury and bladder injury / 中华泌尿外科杂志

Objective To investigate the etiology and treatment of iatrogenic ureteral injury(IUI) and bladder injury(IBI). Methods Forty-seven patients(7 males, 40 females) with ureteral and bladder inju-ries caused as a result of any medical procedures were reviewed from 1996 to 2007. Obstetrics and gynecolog-ical, urological,general surgical procedures were involved in 38, 6, and 4 of the injuries respectively. Re-sults Sixteen cases of IUI were found during operation, including 14 cases of entire ureteral laceration, 4 cases of partial ureteral laceration. Thirteen cases received ureteral anastomosis, one case received uretero-neopyelostomy. One case of ureteral perforations during ureteroscopic procedure was indweUed of double-J after the operation was terminated immediately. Three cases received nephrectomy. Four cases of lower ure-teric suture ligation and three cases of ureterovaginal fistula were detected at 3 days～ one week of postopera-tion. These 7 cases were received ureteroneocystomy during 2 weeks after the initial surgical procedure. Nineteen cases of IBI were found during operation, the length of cystic wound was ranging from 1 cm to 3 cm. 17 cases underwent repairing, 2 eases of bladder perforation which caused by endourologic or TVT procedure received catheterization for 1 week. Five cases of vesicovaginal fistula which were found during one week--one month of post-operation, were received fistula resection and bladder repairing 3 months after of initial operation. Forty-seven cases were follow-up ranging from 5 months to 11 years after the second opera-tion,mean time were 47 months. All cases were recovered. Conclusions Intraoperative findings and effec-tive treatments can achieve good therapeutic effects and avoid injury during secondary operation. Correct treatment of urinary fistula can promote cure rate.

Lesiones de vejiga por trauma abdominal en el Hospital Central de la Cruz Roja Mexicana / Bladder injuries due to abdominal trauma in patients treated at the Central Hospital of the Mexican Red Cross

Introducción: El 10 % de las lesiones traumáticas abdominales involucra la vía urinaria, de éstas 25 % corresponde a trauma vesical. El tipo de lesión depende del mecanismo de acción contuso o penetrante. Los síntomas incluyen hipersensibilidad hipogástrica e imposibilidad para la micción; el signo más importante es la hematuria. Material y métodos: Se realizó estudio retrospectivo observacional y descriptivo de los pacientes con lesión vesical atendidos de enero de 2001 a septiembre de 2007 en el Hospital Central de la Cruz Roja Mexicana de la Ciudad de México; fueron excluidos aquellos con lesiones iatrogénicas. Resultados: Se encontraron 46 casos de lesión vesical, 35 hombres (76 %) y 11 mujeres (24 %). La edad promedio fue de 29 años. El mecanismo de la lesión fue contusión cerrada en 63 % y por herida penetrante en 37 %. El diagnóstico se estableció en 26 % por cistograma retrógrado y en 74 % por laparotomía exploradora, en la cual se identificó lesión asociada de más de dos órganos. El tratamiento dependió de la condición de intra o extraperitoneal; no se informaron complicaciones. Conclusiones: Los pacientes con lesión vesical por trauma son más jóvenes en relación a los que padecen daño iatrogénico y con predominio del sexo masculino. El traumatismo cerrado de abdomen impera sobre el penetrante. La hematuria macroscópica es el síntoma más constante. La lesión vesical asociada a fractura pélvica tuvo baja incidencia. La laparotomía exploradora fue el principal método diagnóstico debido a que lesiones asociadas indicaban la realización inmediata del procedimiento.

BACKGROUND: Abdominal traumas involving the urinary tract represent 10% and, of these, 25% are for bladder trauma. Type of injury depends on the mechanism of action, whether blunt or penetrating. Symptoms include hypogastric hypersensitivity and inability to urinate. The most important sign is hematuria. METHODS: This was a retrospective, observational study and descriptive analysis of patients with bladder injury, excluding iatrogenic injury. RESULTS: There were 46 cases of bladder injury comprising 35 men (76%) and 11 women (24%). Mean age was 29 years. Mechanism of injury was closed contusion (63%) and penetrating wound (37%). Diagnosis was established in 74% of cases by exploratory laparotomy and in 26% of cases by cystography. Treatment was in accordance with intra- or extraperitoneal status, and there were no reported complications. CONCLUSIONS: Patients with traumatic injuries are often young and male, in relation to patients with iatrogenic damage. Closed abdominal trauma is prevalent with penetration. Gross hematuria is the most consistent symptom. Incidence of bladder injury associated with pelvic fracture was low. Exploratory laparotomy was the primary diagnostic method, with cystography done in a limited number of patients. There were no complications.

Urinary Bladder Injury during Pediatric Inguinal Herniorrhaphy

An inguinal hernia is common in pediatric age. However, an in injury to the bladder during hernia repair is quite rare, which may be related to the lack of awareness of the inguinal canal anatomy or inadequate exposure. Gross hematuria and voiding difficulty after herniorrhaphy may indicate a possible injury. Cystography can define the presence and type of injury. An extraperitoneal bladder injury can be managed safely by catheter drainage, antibiotics, and close clinical observations. An intraperitoneal injury requires surgical exploration and bladder closure. We report a case of a urinary bladder injury that was detected after the completion of herniorrhaphy in an eight-year-old girl.

Prevention and treatment of iatrogenic ureter and bladder injury / 解放军医学杂志

Objective To investigate the etiological factors and measures for prevention and treatment of iatrogenic ureteral and bladder injury during obstetric and gynecologic operations.Methods Iatrogenic ureteral and bladder injury happened in 31 patients,who underwent traditional gynecologic operation from June 1996 to May 2006 at the Department of Gynecology and Obstetrics of the Second Affiliated Hospital of Wenzhou Medical College.The etiological factors and treatment for iatrogenic ureteral and bladder injury were analyzed retrospectively.Results The median age of the patients was 44 years(ranged from 27 to 61years).2 cases of iatrogenic ureteral injury and 3 cases of iatrogenic bladder injury occurred in hysterectomy.3 cases of iatrogenic ureteral injury and 2 cases of iatrogenic bladder injure occurred in subtotal hysterectomy for precancerous lesion.5 cases of iatrogenic ureteral injury and 7 cases of iatrogenic bladder injury occurred in radical hysterectomy.One case of iatrogenic ureteral injury and 8 cases of iatrogenic bladder injury occurred in cesarean section.Intraoperative ureteral injury in 7 patients was repaired by end-to-end anastomosis,and intraoperative bladder injury in 15 patients were repaired during operation.In 4 patients the ureteral injury was found after operation,including 2 cases of ureterovaginal fistula,and the injury was repaired after resection of fistulas.Bladder injury was found in 5 cases after operation,and the injuries were repaired by closure of fistulas of bladder 3 months later.All cases recovered with no relapse during the follow-up period of 5 months to 10 years.Conclusions Iatrogenic injury occurs during gynecological surgery should be prevented first.Early discovery and effective treatments can achieve good therapeutic effects.

Clinical Observation on the Bladder and Urethral Injuries / 대한비뇨기과학회지

A clinical observation of the bladder and urethral injuries was made in the army hospital from Jan. to Dec 1968. The results were obtained as follow; 1. The bladder and urethral injuries were 2.3% of all patients treated in the hospital in the last year. 2 The bladder and urethral injuries were 23 cases of the automobile accidents, excluding 3 cases of expulsive injuries and 2 cases of falling accidents 3. The bladder and urethral injuries associated with fracture of pelvic bone were 32.1%, especially 80% in the pubic ramus fracture. 4. The incidence of urethral injury was higher than bladder injury. 5. The complications were urethral stricture (80%). impotence and etc.